RT Journal Article
SR Electronic
T1 The lack of effect of basic and acidic fibroblast growth factors on the naturally occurring death of neurons in the chick embryo
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2726
OP 2734
DO 10.1523/JNEUROSCI.12-07-02726.1992
VO 12
IS 7
A1 RW Oppenheim
A1 D Prevette
A1 F Fuller
YR 1992
UL http://www.jneurosci.org/content/12/7/2726.abstract
AB In vivo treatment of developing chick embryos with acidic and basic fibroblast growth factors (aFGF and bFGF) failed to affect the differentiation and survival of several populations of developing neurons in the CNS and PNS. All of the neuronal populations examined are known to undergo naturally occurring cell death, and they include spinal and cranial motoneurons, dorsal root ganglia, sympathetic ganglia, nodose ganglia, ciliary ganglia, and sympathetic preganglionic neurons in the PNS, as well as the accessory oculomotor nucleus, the isthmo-optic nucleus, and the brainstem auditory nuclei laminaris and magnocellularis in the CNS. Despite the lack of effect of bFGF on neuronal survival and differentiation, in vivo treatment increased the serum levels of bFGF and stimulated the proliferation of non-neuronal cells in the spinal cord. Therefore, although the administration of exogenous FGF to the developing chick embryo in vivo clearly has some biological activity in the CNS, it was nonetheless ineffective in promoting neuronal survival or differentiation. These data do not support the idea that FGF is a physiologically relevant neurotrophic agent in the developing avian nervous system.