PT  - JOURNAL ARTICLE
AU  - A Bulfone
AU  - L Puelles
AU  - MH Porteus
AU  - MA Frohman
AU  - GR Martin
AU  - JL Rubenstein
TI  - Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
AID  - 10.1523/JNEUROSCI.13-07-03155.1993
DP  - 1993 Jul 01
TA  - The Journal of Neuroscience
PG  - 3155--3172
VI  - 13
IP  - 7
4099  - http://www.jneurosci.org/content/13/7/3155.short
4100  - http://www.jneurosci.org/content/13/7/3155.full
SO  - J. Neurosci.1993 Jul 01; 13
AB  - The expression patterns of four genes that are potential regulators of development were examined in the CNS of the embryonic day 12.5 mouse embryo. Three of the genes, Dlx-1, Dlx-2 (Tes-1), and Gbx-2, encode homeodomain-containing proteins, and one gene, Wnt-3, encodes a putative secreted differentiation factor. These genes are expressed in spatially restricted transverse and longitudinal domains in the embryonic neural tube, and are also differentially expressed within the wall of the neural tube. Dlx-1 and Dlx-2 are expressed in two separate regions of the forebrain in an identical pattern. The Gbx-2 gene is expressed in four domains, two of which share sharp boundaries with the domains of the Dlx genes. One boundary is in the basal telecephalon between deep and superficial strata of the medial ganglionic eminence; the other boundary is in the diencephalon at the zona limitans intrathalamica. The Wnt-3 gene is expressed in a dorsal longitudinal zone extending from the hindbrain into the diencephalon, where its expression terminates at the zona limitans intrathalamica. Reciprocal patterns of expression are found within the dorsal thalamus for the Gbx- 2 and Wnt-3 genes. These findings are consistent with neuromeric theories of forebrain development, and based upon them we suggest a model for forebrain segmentation.