RT Journal Article
SR Electronic
T1 Enhancement by anesthetic and convulsant barbiturates of GABA binding to rat brain synaptosomal membranes
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 364
OP 367
DO 10.1523/JNEUROSCI.01-04-00364.1981
VO 1
IS 4
A1 M Willow
A1 GA Johnston
YR 1981
UL http://www.jneurosci.org/content/1/4/364.abstract
AB All of the anesthetic (amylobarbitone, butobarbitone, pentobarbitone, phenobarbitone, and secobarbitone) and convulsant (5-ethyl-5(3′- methylbut-2-enyl) barbituric acid (3M2B) and 5-ethyl-5-(2′- cyclohexylidene-ethyl) barbituric acid (CHEB) barbiturates tested enhanced the binding of GABA to a carefully prepared P2 membrane fraction from rat brain in a dose-dependent manner. These findings are in agreement with the potentiation of the inhibitory effects of GABA in many neuronal systems by both classes of barbiturates.