TY - JOUR T1 - Gases as biological messengers: nitric oxide and carbon monoxide in the brain JF - The Journal of Neuroscience JO - J. Neurosci. SP - 5147 LP - 5159 DO - 10.1523/JNEUROSCI.14-09-05147.1994 VL - 14 IS - 9 AU - TM Dawson AU - SH Snyder Y1 - 1994/09/01 UR - http://www.jneurosci.org/content/14/9/5147.abstract N2 - In a remarkably brief period of time, NO and CO have been recognized as putative neurotransmitters. These two novel messenger molecules have greatly expanded the criteria for candidacy of a chemical for the status of neurotransmitter and our notions about how synaptic transmission takes place. The involvement of NO and CO in several important aspects of neuronal function suggests that agents affecting the synthesis, transactions, and disposition of these gases are bound to have clinical relevance. ER -