PT  - JOURNAL ARTICLE
AU  - SS Scherer
AU  - SM Deschenes
AU  - YT Xu
AU  - JB Grinspan
AU  - KH Fischbeck
AU  - DL Paul
TI  - Connexin32 is a myelin-related protein in the PNS and CNS
AID  - 10.1523/JNEUROSCI.15-12-08281.1995
DP  - 1995 Dec 01
TA  - The Journal of Neuroscience
PG  - 8281--8294
VI  - 15
IP  - 12
4099  - http://www.jneurosci.org/content/15/12/8281.short
4100  - http://www.jneurosci.org/content/15/12/8281.full
SO  - J. Neurosci.1995 Dec 01; 15
AB  - We have examined the expression of a gap junction protein, connexin32 (Cx32), in Schwann cells and oligodendrocytes. In peripheral nerve, Cx32 is found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells, and the levels of Cx32 protein and mRNA change in parallel with those of other myelin-related genes during development, Wallerian degeneration, and axonal regeneration. In the central nervous system, Cx32 is found in oligodendrocytes and their processes, but not in compact myelin, and the levels of Cx32 protein and mRNA increase during development in parallel with those of the other myelin genes. Thus, Cx32 is expressed as part of the myelinating phenotype of both Schwann cells and oligodendrocytes, indicating that this gap junction protein plays in important role in the biology of myelin-forming cells.