RT Journal Article
SR Electronic
T1 The loss of neuron-specific proteins during the course of Wallerian degeneration of optic and sciatic nerve
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 461
OP 470
DO 10.1523/JNEUROSCI.01-05-00461.1981
VO 1
IS 5
A1 D Soifer
A1 K Iqbal
A1 H Czosnek
A1 J De Martini
A1 JA Sturman
A1 HM Wisniewski
YR 1981
UL http://www.jneurosci.org/content/1/5/461.abstract
AB To identify axonal proteins which are unique constituents of neurons, the spectrum of detectable proteins of degenerating nerves has been compared with that of intact control nerves from the same animals. Wallerian degeneration was induced in rabbits by unilateral transection of the optic and sciatic nerves. Proteins of nerve homogenates were compared by sodium dodecyl sulfate-gel electrophoresis and by two- dimensional electrophoresis. Four non-myelin proteins disappear from degenerating nerve. These include the three neurofilament proteins (P68, P150, and P200) and a polypeptide with a molecular weight of about 65,000 daltons (P65) which is not associated with filaments.