RT Journal Article
SR Electronic
T1 A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 2057
OP 2063
DO 10.1523/JNEUROSCI.16-06-02057.1996
VO 16
IS 6
A1 U Frey
A1 M Muller
A1 D Kuhl
YR 1996
UL http://www.jneurosci.org/content/16/6/2057.abstract
AB The establishment of hippocampal long-term (LTP) requires protein and mRNA synthesis, suggesting that neuronal activity resulting in LTP initiates a cascade of gene expression. The expression of the gene for the extracellular serine protease tissue plasminogen activator (t-PA) is induced during LTP. Here we analyze long-lasting LTP (L-LTP,>4 hr)in CA1 hippocampal slices of mice homozygous for disrupted t-PA genes. Although mutant mice appear to exhibit long-term potentiation, we provide evidence that these mice are devoid of conventional homosynaptic L-LTP at the Schaffer collateral-CA1 pyramidal cell synapse. Most remarkably, t-PA-deficient mice exhibit a different form of long-lasting potentiation that is characterized by an NMDA receptor- dependent modification of GABA transmission in the CA1 region.