RT Journal Article
SR Electronic
T1 Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6988
OP 6998
DO 10.1523/JNEUROSCI.17-18-06988.1997
VO 17
IS 18
A1 Marta Majdan
A1 Christian Lachance
A1 Andrew Gloster
A1 Raquel Aloyz
A1 Christine Zeindler
A1 Shernaz Bamji
A1 Asha Bhakar
A1 Daniel Belliveau
A1 James Fawcett
A1 Freda D. Miller
A1 Philip A. Barker
YR 1997
UL http://www.jneurosci.org/content/17/18/6988.abstract
AB We have asked whether p75NTR may play a role in neuronal apoptosis by producing transgenic mice that express the p75NTR intracellular domain within peripheral and central neurons. These animals showed profound reductions in numbers of sympathetic and peripheral sensory neurons as well as cell loss in the neocortex, where there is normally little or no p75NTR expression. Developmental loss of facial motor neurons was not observed, but induced expression of the p75NTR intracellular domain within adult animals led to increased motor neuron death after axotomy. Biochemical analyses suggest that these effects were not attributable to a p75NTR-dependent reduction in trk activation but instead indicate that the p75NTR intracellular domain may act as a constitutive activator of signaling cascades that regulate apoptosis in both peripheral and central neurons.