PT  - JOURNAL ARTICLE
AU  - Christopher S. Wallace
AU  - Gregory L. Lyford
AU  - Paul F. Worley
AU  - Oswald Steward
TI  - Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence
AID  - 10.1523/JNEUROSCI.18-01-00026.1998
DP  - 1998 Jan 01
TA  - The Journal of Neuroscience
PG  - 26--35
VI  - 18
IP  - 1
4099  - http://www.jneurosci.org/content/18/1/26.short
4100  - http://www.jneurosci.org/content/18/1/26.full
SO  - J. Neurosci.1998 Jan 01; 18
AB  - This study characterizes the differential targeting of recently synthesized immediate early gene (IEG) mRNAs to neuronal cell bodies versus dendrites and tests the hypothesis that this targeting is based on signals in the encoded proteins. A single electroconvulsive seizure induces the expression of a number of IEG mRNAs in granule cells of the dentate gyrus. Most of these IEG mRNAs remain in the cell body, including two that are characterized in the present study (the mRNAs for NGFI-A and COX-2). In contrast, the mRNA for Arcmoved rapidly into dendrites at an apparent rate of ∼300 μm/hr. Inhibiting protein synthesis with cycloheximide did not disrupt the differential mRNA sorting, demonstrating that the differential targeting of mRNAs is not dependent on translation.