TY - JOUR T1 - Mouse <em>Zic1</em> Is Involved in Cerebellar Development JF - The Journal of Neuroscience JO - J. Neurosci. SP - 284 LP - 293 DO - 10.1523/JNEUROSCI.18-01-00284.1998 VL - 18 IS - 1 AU - Jun Aruga AU - Osamu Minowa AU - Hiroyuki Yaginuma AU - Junko Kuno AU - Takeharu Nagai AU - Tetsuo Noda AU - Katsuhiko Mikoshiba Y1 - 1998/01/01 UR - http://www.jneurosci.org/content/18/1/284.abstract N2 - Zic genes encode zinc finger proteins, the expression of which is highly restricted to cerebellar granule cells and their precursors. These genes are homologs of theDrosophila pair-rule gene odd-paired. To clarify the role of the Zic1 gene, we have generated mice deficient in Zic1. Homozygous mice showed remarkable ataxia during postnatal development. Nearly all of the mice died within 1 month. Their cerebella were hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from 14 d postcoitum, and in forward movement of the EGL. These findings suggest thatZic1 may determine the cerebellar folial pattern principally via regulation of cell proliferation in the EGL. ER -