RT Journal Article
SR Electronic
T1 Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 5456
OP 5462
DO 10.1523/JNEUROSCI.18-14-05456.1998
VO 18
IS 14
A1 Lisa R. Banner
A1 Paul H. Patterson
A1 Andrew Allchorne
A1 Steve Poole
A1 Clifford J. Woolf
YR 1998
UL http://www.jneurosci.org/content/18/14/5456.abstract
AB The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund’s adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is enhanced in spatial extent, amplitude, cellular infiltrate, and interleukin (IL)-1β and nerve growth factor (NGF) expression. Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1β and NGF expression induced by CFA. These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia.