RT Journal Article
SR Electronic
T1 Slow Oscillations (≤1 Hz) Mediated by GABAergic Interneuronal Networks in Rat Hippocampus
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9256
OP 9268
DO 10.1523/JNEUROSCI.18-22-09256.1998
VO 18
IS 22
A1 Y. Zhang
A1 J. L. Perez Velazquez
A1 G. F. Tian
A1 C.-P. Wu
A1 F. K. Skinner
A1 P. L. Carlen
A1 L. Zhang
YR 1998
UL http://www.jneurosci.org/content/18/22/9256.abstract
AB Perfusion of rat brain slices with low millimole CsCl elicits slow oscillations of ≤1 Hz in hippocampal CA1 pyramidal neurons. These oscillations are GABAA receptor-mediated hyperpolarizations that permit a coherent fire–pause pattern in a population of CA1 neurons. They can persist without the activation of ionotropic glutamate receptors but require adenosine-dependent inhibition of glutamate transmission. In response to external Cs+, multiple interneurons in the CA1 region display rhythmic discharges that correlate with the slow oscillations in CA1 pyramidal neurons. The interneuronal discharges arise spontaneously from the resting potential, and their rhythmicity is regulated by periodic, GABAA receptor-mediated hyperpolarizations. In addition, interneurons show periodic partial spikes and neurobiotin coupling, and applications of known gap junctional uncouplers interrupt the Cs+-induced slow rhythm in both CA1 pyramidal neurons and interneurons. We propose that these slow oscillations originate from a GABAergic interneuronal network that interacts through reciprocal inhibition and possibly gap junctional connection.