PT  - JOURNAL ARTICLE
AU  - Gordon Winocur
AU  - Morris Moscovitch
TI  - Anterograde and Retrograde Amnesia After Lesions to Frontal Cortex in Rats
AID  - 10.1523/JNEUROSCI.19-21-09611.1999
DP  - 1999 Nov 01
TA  - The Journal of Neuroscience
PG  - 9611--9617
VI  - 19
IP  - 21
4099  - http://www.jneurosci.org/content/19/21/9611.short
4100  - http://www.jneurosci.org/content/19/21/9611.full
SO  - J. Neurosci.1999 Nov 01; 19
AB  - A socially acquired food-preference test was used to assess effects of lesions to the frontal cortex on anterograde and retrograde memory in rats. In Experiment 1, there was no effect of lesion when rats were administered a two-choice test in which the target food was to be selected in the presence of a single distractor. In Experiment 2, a three-choice memory test was administered in which the target food was presented along with two equally palatable alternatives. In the latter test, lesioned groups displayed anterograde amnesia that increased with the length of the interval between postoperative acquisition and test, and a severe retrograde amnesia that extended equally over the entire range of intervals between preoperative acquisition and test. This outcome, which contrasted with the pattern of memory loss previously observed in rats with hippocampal lesions on this test, was interpreted as evidence for the strategic role of the frontal lobes in directing response selection and retrieval processes in memory.