TY - JOUR T1 - Signal Transfer in Passive Dendrites with Nonuniform Membrane Conductance JF - The Journal of Neuroscience JO - J. Neurosci. SP - 8219 LP - 8233 DO - 10.1523/JNEUROSCI.19-19-08219.1999 VL - 19 IS - 19 AU - Michael London AU - Claude Meunier AU - Idan Segev Y1 - 1999/10/01 UR - http://www.jneurosci.org/content/19/19/8219.abstract N2 - In recent years it became clear that dendrites possess a host of ion channels that may be distributed nonuniformly over their membrane surface. In cortical pyramids, for example, it was demonstrated that the resting membrane conductance Gm(x) is higher (the membrane is “leakier”) at distal dendritic regions than at more proximal sites. How does this spatial nonuniformity in Gm(x) affect the input–output function of the neuron? The present study aims at providing basic insights into this question. To this end, we have analytically studied the fundamental effects of membrane non-uniformity in passive cable structures.Keeping the total membrane conductance over a given modeled structure fixed (i.e., a constant number of passive ion channels), the classical case of cables with uniform membrane conductance is contrasted with various nonuniform cases with the following general conclusions. (1) For cylindrical cables with “sealed ends,” monotonic increase in Gm(x) improves voltage transfer from the input location to the soma. The steeper the Gm(x), the larger the improvement. (2) This effect is further enhanced when the stimulation is distal and consists of a synaptic input rather than a current source. (3) Any nonuniformity in Gm(x) decreases the electrotonic length, L, of the cylinder. (4) The system time constant τ0 is larger in the nonuniform case than in the corresponding uniform case. (5) When voltage transients relax with τ0, the dendritic tree is not isopotential in the nonuniform case, at variance with the uniform case. The effect of membrane nonuniformity on signal transfer in reconstructed dendritic trees and on the I/f relation of the neuron is also considered, and experimental methods for assessing membrane nonuniformity in dendrites are discussed. ER -