PT  - JOURNAL ARTICLE
AU  - Virgil Muresan
AU  - Asya Lyass
AU  - Bruce J. Schnapp
TI  - The Kinesin Motor KIF3A Is a Component of the Presynaptic Ribbon in Vertebrate Photoreceptors
AID  - 10.1523/JNEUROSCI.19-03-01027.1999
DP  - 1999 Feb 01
TA  - The Journal of Neuroscience
PG  - 1027--1037
VI  - 19
IP  - 3
4099  - http://www.jneurosci.org/content/19/3/1027.short
4100  - http://www.jneurosci.org/content/19/3/1027.full
SO  - J. Neurosci.1999 Feb 01; 19
AB  - Kinesin motors are presumed to transport various membrane compartments within neurons, but their specific in vivofunctions, cargoes, and expression patterns in the brain are unclear. We have investigated the distribution of KIF3A, a member of the heteromeric family of kinesins, in the vertebrate retina. We find KIF3A at two distinct sites within photoreceptors: at the basal body of the connecting cilium axoneme and at the synaptic ribbon. Immunoelectron microscopy of the photoreceptor ribbon synapse shows KIF3A to be concentrated both at the ribbon matrix and on vesicles docked at the ribbon, a result that is consistent with the presence of both detergent-extractable and resistant KIF3A fractions at these synapses. KIF3A is also present in the inner plexiform layer, again at presynaptic ribbons. These findings suggest that within a single cell, the photoreceptor, one kinesin polypeptide, KIF3A, can serve two distinct functions, one specific for ribbon synapses.