RT Journal Article
SR Electronic
T1 Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 5516
OP 5525
DO 10.1523/JNEUROSCI.20-14-05516.2000
VO 20
IS 14
A1 Javier F. Medina
A1 Keith S. Garcia
A1 William L. Nores
A1 Nichole M. Taylor
A1 Michael D. Mauk
YR 2000
UL http://www.jneurosci.org/content/20/14/5516.abstract
AB We used large-scale computer simulations of eyelid conditioning to investigate how the cerebellum generates and makes use of temporal information. In the simulations the adaptive timing displayed by conditioned responses is mediated by two factors: (1) different sets of granule cells are active at different times during the conditioned stimulus (CS), and (2) responding is not only amplified at reinforced times but also suppressed at unreinforced times during the CS. These factors predict an unusual pattern of responding after partial removal of the cerebellar cortex that was confirmed using small, electrolytic lesions of cerebellar cortex. These results are consistent with timing mechanisms in the cerebellum that are similar to Pavlov's “inhibition of delay” hypothesis.