TY - JOUR T1 - Differential Expression of Plasticity-Related Genes in Waking and Sleep and Their Regulation by the Noradrenergic System JF - The Journal of Neuroscience JO - J. Neurosci. SP - 9187 LP - 9194 DO - 10.1523/JNEUROSCI.20-24-09187.2000 VL - 20 IS - 24 AU - Chiara Cirelli AU - Giulio Tononi Y1 - 2000/12/15 UR - http://www.jneurosci.org/content/20/24/9187.abstract N2 - Behavioral studies indicate that the ability to acquire long-term memories is severely impaired during sleep. It is unclear, however, why the highly synchronous discharge of neurons during sleep should not be followed by the induction of enduring plastic changes. Here we show that the expression of phosphorylated CRE-binding protein, Arc, andBDNF, three genes whose induction is often associated with synaptic plasticity, is high during waking and low during sleep. We also show that the induction of these genes during waking depends on the activity of the noradrenergic system, which is high in waking and low in sleep. These molecular results complement behavioral evidence and provide a mechanism for the impairment of long-term memory acquisition during sleep. ER -