RT Journal Article
SR Electronic
T1 Role of Voltage-Dependent Calcium Channel Long-Term Potentiation (LTP) and NMDA LTP in Spatial Memory
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9272
OP 9276
DO 10.1523/JNEUROSCI.20-24-09272.2000
VO 20
IS 24
A1 Albert M. Borroni
A1 Harlan Fichtenholtz
A1 Brian L. Woodside
A1 Timothy J. Teyler
YR 2000
UL http://www.jneurosci.org/content/20/24/9272.abstract
AB This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 d period, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).