RT Journal Article
SR Electronic
T1 Proteomics in Neuroscience: From Protein to Network
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 8315
OP 8318
DO 10.1523/JNEUROSCI.21-21-08315.2001
VO 21
IS 21
A1 Seth G. N. Grant
A1 Walter P. Blackstock
YR 2001
UL http://www.jneurosci.org/content/21/21/8315.abstract
AB Proteomic tools offer a new platform for studies of complex biological functions involving large numbers and networks of proteins. Intracellular networks of proteins perform key functions in neurons and glia. The unicellular eukaryote Saccharomyces cerevisiae has been the prototype for eukaryotic proteomic studies, and when combined with genomics, microarrays, genetics, and pharmacology, new insights into the integrated function of the cell emerge. The anatomical complexity of the nervous system both in cell types and in the vast number of synapses introduces novel technical and biological issues regarding the subcellular organization of protein networks. Here we will discuss the technology of proteomics and its applications to the nervous system.