RT Journal Article
SR Electronic
T1 Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 133
OP 141
DO 10.1523/JNEUROSCI.22-01-00133.2002
VO 22
IS 1
A1 Kentaro Tanemura
A1 Miyuki Murayama
A1 Takumi Akagi
A1 Tsutomu Hashikawa
A1 Takashi Tominaga
A1 Michinori Ichikawa
A1 Haruyasu Yamaguchi
A1 Akihiko Takashima
YR 2002
UL http://www.jneurosci.org/content/22/1/133.abstract
AB Formation of neurofibrillary tangles (NFTs) is a common neuropathological feature found in several neurodegenerative diseases, including Alzheimer's disease. We have developed a transgenic (Tg) mouse expressing mutant human tau (V337M), derived from frontotemporal dementia parkinsonism-17. V337M Tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for NFTs in human neurodegenerative diseases. Concurrent with the accumulation of RNA and phosphorylated tau, neurons exhibited morphological characteristics of degenerating neurons, which include a loss of microtubules, accumulation of ribosomes, plasma and nuclear membrane ruffling, and swelling of the Golgi network. Thus, mutant tau induces neuronal degeneration associated with the accumulation of RNA and phosphorylated tau. The functional consequences of this neuronal degeneration was evidenced by the reduction of hippocampal neural activity and behavioral abnormality in Tg mice.