RT Journal Article
SR Electronic
T1 Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 5797
OP 5802
DO 10.1523/JNEUROSCI.22-14-05797.2002
VO 22
IS 14
A1 Carola A. Haas
A1 Oliver Dudeck
A1 Matthias Kirsch
A1 Csaba Huszka
A1 Gunda Kann
A1 Stefan Pollak
A1 Josef Zentner
A1 Michael Frotscher
YR 2002
UL http://www.jneurosci.org/content/22/14/5797.abstract
AB The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain. Reelin, which is synthesized and secreted by Cajal–Retzius cells in the marginal zone of the neocortex and hippocampus, is proposed to act as a stop signal for migrating neurons. Here we show that a decreased expression of reelin mRNA by hippocampal Cajal–Retzius cells correlates with the extent of migration defects in the dentate gyrus of patients with temporal lobe epilepsy. These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy.