RT Journal Article
SR Electronic
T1 Mammalian Achaete Scute Homolog 2 Is Expressed in the Adult Sciatic Nerve and Regulates the Expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann Cells
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 7586
OP 7595
DO 10.1523/JNEUROSCI.22-17-07586.2002
VO 22
IS 17
A1 Patrick Küry
A1 Regine Greiner-Petter
A1 Christiane Cornely
A1 Tim Jürgens
A1 Hans Werner Müller
YR 2002
UL http://www.jneurosci.org/content/22/17/7586.abstract
AB The molecular control mechanisms and regulatory molecules involved in nerve repair are not yet well known. Schwann cells have been attributed an important role in peripheral nerve regeneration; therefore, attention has been drawn to regulatory factors expressed by these glial cells. Here, we demonstrate that Mash2, a basic helix–loop–helix (bHLH) transcription factor previously shown to be crucial for placenta development, is expressed by Schwann cells of adult peripheral nerves. We observed that this gene is downregulated after nerve lesion and, using cDNA array hybridization technology, we could demonstrate that Mash2 is a regulator of Krox24, Mob-1, and CXCR4 expression in cultured Schwann cells. In addition, we provide strong evidence that Mash2 is a negative regulator of Schwann cell proliferation. Mash2 represents a first candidate for the missing class B bHLH proteins in peripheral nerves.