TY - JOUR T1 - The Hippocampus Plays an Important Role in Eyeblink Conditioning with a Short Trace Interval in Glutamate Receptor Subunit δ2 Mutant Mice JF - The Journal of Neuroscience JO - J. Neurosci. SP - 17 LP - 22 DO - 10.1523/JNEUROSCI.23-01-00017.2003 VL - 23 IS - 1 AU - Kanako Takatsuki AU - Shigenori Kawahara AU - Sadaharu Kotani AU - Satoshi Fukunaga AU - Hisashi Mori AU - Masayoshi Mishina AU - Yutaka Kirino Y1 - 2003/01/01 UR - http://www.jneurosci.org/content/23/1/17.abstract N2 - Mutant mice lacking the glutamate receptor subunit δ2 exhibit changes in the structure and function of the cerebellar cortex. The most prominent functional feature is a deficiency in the long-term depression (LTD) at parallel fiber–Purkinje cell synapses. These mutant mice exhibit severe impairment during delay eyeblink conditioning but learn normally during trace eyeblink conditioning without the cerebellar LTD, even with a 0 trace interval. We investigated the hippocampal contribution to this cerebellar LTD-independent “0 trace interval” learning. The mutant mice whose dorsal hippocampi were aspirated exhibited severe impairment in learning, whereas those that received post-training hippocampal lesions retained the memory. The wild-type mice showed no impairment in either case. These results suggest that the hippocampal component of the eyeblink conditioning task becomes dominant when cerebellar LTD is impaired. ER -