RT Journal Article
SR Electronic
T1 Dopamine Modulation of Perisomatic and Peridendritic Inhibition in Prefrontal Cortex
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1622
OP 1630
DO 10.1523/JNEUROSCI.23-05-01622.2003
VO 23
IS 5
A1 Wen-Jun Gao
A1 Yun Wang
A1 Patricia S. Goldman-Rakic
YR 2003
UL http://www.jneurosci.org/content/23/5/1622.abstract
AB The computations underlying cognitive functions are performed by a diversity of interactions between interneurons and pyramidal neurons that are subject to modulatory influences. Here we have used paired whole-cell recording to study the influence of dopamine on local inhibitory circuits involving fast-spiking (FS) and non-FS cells, respectively. We found that dopamine depressed inhibitory transmission between FS interneurons and pyramidal neurons but enhanced inhibition between non-FS interneurons and pyramidal cells. FS inhibitory transmission exhibited properties associated with presynaptic action at D1 receptors that were not evident in non-FS inhibitory connections. In addition, FS and non-FS interneurons differed morphologically, forming contacts on the perisomatic and peridendritic domains, respectively, of their pyramidal cell targets. These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine.