PT  - JOURNAL ARTICLE
AU  - Constantinos D. Paspalas
AU  - Patricia S. Goldman-Rakic
TI  - Microdomains for Dopamine Volume Neurotransmission in Primate Prefrontal Cortex
AID  - 10.1523/JNEUROSCI.0195-04.2004
DP  - 2004 Jun 09
TA  - The Journal of Neuroscience
PG  - 5292--5300
VI  - 24
IP  - 23
4099  - http://www.jneurosci.org/content/24/23/5292.short
4100  - http://www.jneurosci.org/content/24/23/5292.full
SO  - J. Neurosci.2004 Jun 09; 24
AB  - The explicit yet enigmatic involvement of dopamine in cortical physiology is in part volumetric (beyond the synapse), as is apparently the action of neuroleptics targeting dopamine receptors. The notion that nonsynaptic neuronal membranes would translate extracellular dopamine into receptor-specific spatiotemporal downstream signaling, similar to the chemical synapse, is intriguing. Here, we report that dopamine D5 (but not D1 or D2) receptors in the perisomatic plasma membrane of prefrontal cortical neurons form discrete and exclusively extrasynaptic microdomains with inositol 1,4,5-trisphosphate-gated calcium stores of subsurface cisterns and mitochondria. These findings introduce a novel dopaminoceptive substratum in the brain and a unique D5 receptor-specific signaling paradigm.