%0 Journal Article %A Ira Espuny Camacho %A Lutgarde Serneels %A Kurt Spittaels %A Pascal Merchiers %A Diana Dominguez %A Bart De Strooper %T Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide %D 2004 %R 10.1523/JNEUROSCI.3987-04.2004 %J The Journal of Neuroscience %P 10908-10917 %V 24 %N 48 %X We investigated whether peroxisome proliferator-activated receptor γ (PPARγ) could be involved in the modulation of the amyloid cascade causing Alzheimer's disease. Inducing expression or activating PPARγ using synthetic agonists of the thiazolinedione family results in a dramatic decrease in the levels of the amyloid-β (Aβ) peptide in the conditioned medium of neuronal and non-neuronal cells. PPARγ does not affect expression or activity of any of the secretases involved in the generation of the Aβ peptide but induces a fast, cell-bound clearing mechanism responsible for the removal of the Aβ peptide from the medium. Although PPARγ expression is generally low in the CNS, induction of PPARγ expression during inflammation could be beneficial for inducing Aβ clearance. We confirm that the Aβ clearance mechanism can indeed be induced by PPARγ activation in primary murine-mixed glia and cortical neuronal cultures. Our results suggest that PPARγ-controlled mechanisms should be explored further as potential drug targets for Alzheimer's disease treatment. %U https://www.jneurosci.org/content/jneuro/24/48/10908.full.pdf