RT Journal Article
SR Electronic
T1 Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 7709
OP 7717
DO 10.1523/JNEUROSCI.2177-05.2005
VO 25
IS 34
A1 Randy L. Buckner
A1 Abraham Z. Snyder
A1 Benjamin J. Shannon
A1 Gina LaRossa
A1 Rimmon Sachs
A1 Anthony F. Fotenos
A1 Yvette I. Sheline
A1 William E. Klunk
A1 Chester A. Mathis
A1 John C. Morris
A1 Mark A. Mintun
YR 2005
UL http://www.jneurosci.org/content/25/34/7709.abstract
AB Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies. In total, data from 764 participants were compared across five in vivo imaging methods. Convergence of effects was seen in posterior cortical regions, including posterior cingulate, retrosplenial, and lateral parietal cortex. These regions were active in default states in young adults and also showed amyloid deposition in older adults with AD. At early stages of AD progression, prominent atrophy and metabolic abnormalities emerged in these posterior cortical regions; atrophy in medial temporal regions was also observed. Event-related functional magnetic resonance imaging studies further revealed that these cortical regions are active during successful memory retrieval in young adults. One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy. These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.