PT  - JOURNAL ARTICLE
AU  - Alicia Izquierdo
AU  - Robin K. Suda
AU  - Elisabeth A. Murray
TI  - Comparison of the Effects of Bilateral Orbital Prefrontal Cortex Lesions and Amygdala Lesions on Emotional Responses in Rhesus Monkeys
AID  - 10.1523/JNEUROSCI.1232-05.2005
DP  - 2005 Sep 14
TA  - The Journal of Neuroscience
PG  - 8534--8542
VI  - 25
IP  - 37
4099  - http://www.jneurosci.org/content/25/37/8534.short
4100  - http://www.jneurosci.org/content/25/37/8534.full
SO  - J. Neurosci.2005 Sep 14; 25
AB  - The present study examines the effects of bilateral orbital prefrontal cortex (PFo) lesions on monkeys' emotional responses in two different contexts: in the presence of a rubber snake and in the presence of a human intruder. For comparison, we also assessed the responses of rhesus monkeys with selective amygdala lesions on these same tasks. Monkeys with PFo lesions, like those with amygdala lesions, displayed blunted emotional responses to the fake snake. Unlike monkeys with amygdala lesions, however, monkeys with PFo lesions displayed more mild aggression than controls in the presence of a human intruder. The findings support the idea that the PFo helps integrate sensory signals in the service of choosing among competing responses. In addition, they point to a divergence of the roles of the PFo and amygdala in responding to a social stimulus, the human intruder.