PT  - JOURNAL ARTICLE
AU  - EF Hahn
AU  - M Carroll-Buatti
AU  - GW Pasternak
TI  - Irreversible opiate agonists and antagonists: the 14- hydroxydihydromorphinone azines
AID  - 10.1523/JNEUROSCI.02-05-00572.1982
DP  - 1982 May 01
TA  - The Journal of Neuroscience
PG  - 572--576
VI  - 2
IP  - 5
4099  - http://www.jneurosci.org/content/2/5/572.short
4100  - http://www.jneurosci.org/content/2/5/572.full
SO  - J. Neurosci.1982 May 01; 2
AB  - Further investigations into the molecular actions of the 14- hydroxydihydromorphinone hydrazones (naloxazone, oxymorphazone, and naltrexazone) have suggested that their irreversible actions can be explained by the formation of their azines. These azines, naloxonazine, naltrexonazine, and oxymorphonazine, irreversibly block opiate binding in vitro 20- to 40-fold more potently than their corresponding hydrozones, naloxazone, naltrexazone, and oxymorphazone. The blockade of binding by naloxonazine shows the same selectivity for high affinity, or mu1, sites as naloxazone.