PT  - JOURNAL ARTICLE
AU  - Ralph Feuer
AU  - Robb R. Pagarigan
AU  - Stephanie Harkins
AU  - Fei Liu
AU  - Isabelle P. Hunziker
AU  - J. Lindsay Whitton
TI  - Coxsackievirus Targets Proliferating Neuronal Progenitor Cells in the Neonatal CNS
AID  - 10.1523/JNEUROSCI.4517-04.2005
DP  - 2005 Mar 02
TA  - The Journal of Neuroscience
PG  - 2434--2444
VI  - 25
IP  - 9
4099  - http://www.jneurosci.org/content/25/9/2434.short
4100  - http://www.jneurosci.org/content/25/9/2434.full
SO  - J. Neurosci.2005 Mar 02; 25
AB  - Type B coxsackieviruses (CVB) frequently infect the CNS and, together with other enteroviruses, are the most common cause of viral meningitis in humans. Newborn infants are particularly vulnerable, and CVB also can infect the fetus, leading to mortality, or to neurodevelopmental defects in surviving infants. Using a mouse model of neonatal CVB infection, we previously demonstrated that coxsackievirus B3 (CVB3) could infect neuronal progenitor cells in the subventricular zone (SVZ). Here we extend these findings, and we show that CVB3 targets actively proliferating (bromodeoxyuridine+, Ki67+) cells in the SVZ, including type B and type A stem cells. However, infected cells exiting the SVZ have lost their proliferative capacity, in contrast to their uninfected companions. Despite being proliferation deficient, the infected neuronal precursors could migrate along the rostral migratory stream and radial glia, to reach their final destinations in the olfactory bulb or cerebral cortex. Furthermore, infection did not prevent cell differentiation, as determined by cellular morphology and the expression of maturation markers. These data lead us to propose a model of CVB infection of the developing CNS, which may explain the neurodevelopmental defects that result from fetal infection.