PT - JOURNAL ARTICLE AU - Brad E. Pfeiffer AU - Kimberly M. Huber TI - Current Advances in Local Protein Synthesis and Synaptic Plasticity AID - 10.1523/JNEUROSCI.1797-06.2006 DP - 2006 Jul 05 TA - The Journal of Neuroscience PG - 7147--7150 VI - 26 IP - 27 4099 - http://www.jneurosci.org/content/26/27/7147.short 4100 - http://www.jneurosci.org/content/26/27/7147.full SO - J. Neurosci.2006 Jul 05; 26 AB - Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.