RT Journal Article
SR Electronic
T1 Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 7151
OP 7155
DO 10.1523/JNEUROSCI.1790-06.2006
VO 26
IS 27
A1 Aaron W. Grossman
A1 Georgina M. Aldridge
A1 Ivan Jeanne Weiler
A1 William T. Greenough
YR 2006
UL http://www.jneurosci.org/content/26/27/7151.abstract
AB Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).