TY - JOUR T1 - The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation JF - The Journal of Neuroscience JO - J. Neurosci. SP - 7156 LP - 7162 DO - 10.1523/JNEUROSCI.0906-06.2006 VL - 26 IS - 27 AU - Y. M. Lisa Chuah AU - Vinod Venkatraman AU - David F. Dinges AU - Michael W. L. Chee Y1 - 2006/07/05 UR - http://www.jneurosci.org/content/26/27/7156.abstract N2 - Sleep deprivation results in the loss of our ability to suppress a prepotent response. The extent of decline in this executive function varies across individuals. Here, we used functional magnetic resonance imaging to study the neural correlates of sleep deprivation-induced differences in inhibitory efficiency. Participants performed a go/no-go task after normal sleep and after 24 h of total sleep deprivation. Regardless of the extent of change in inhibitory efficiency, sleep deprivation lowered go/no-go sustained, task-related activation of the ventral and anterior prefrontal (PFC) regions bilaterally. However, individuals better able to maintain inhibitory efficiency after sleep deprivation could be distinguished by lower stop-related, phasic activation of the right ventral PFC during rested wakefulness. These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined. ER -