TY - JOUR T1 - Increased Generation of Neuronal Progenitors after Ischemic Injury in the Aged Adult Human Forebrain JF - The Journal of Neuroscience JO - J. Neurosci. SP - 13114 LP - 13119 DO - 10.1523/JNEUROSCI.4667-06.2006 VL - 26 IS - 50 AU - Jadranka Macas AU - Christian Nern AU - Karl H. Plate AU - Stefan Momma Y1 - 2006/12/13 UR - http://www.jneurosci.org/content/26/50/13114.abstract N2 - The adult human brain retains the capacity to generate new neurons in the hippocampal formation (Eriksson et al., 1998) and neuronal progenitor cells (NPCs) in the forebrain (Bernier et al., 2000), but to what extent it is capable of reacting to injuries, such as ischemia, is not known. We analyzed postmortem tissue from normal and pathological human brain tissue (n = 54) to study the cellular response to ischemic injury in the forebrain. We observed that cells expressing the NPC marker polysialylated neural adhesion cell molecule (PSA-NCAM) are continuously generated in the adult human subventricular zone (SVZ) and migrate along the olfactory tracts. These cells were not organized in migrating chains as in the adult rodent rostral migratory stream, and their number was lower in the olfactory tracts of brains from old (56–81 years of age) compared with young (29 + 36 years of age) individuals. Moreover, we show that in brains of patients of advanced age (60–87 years of age), ischemia led to an elevated number of Ki-67-positive cells in the ipsilateral SVZ without concomitant apoptotic cell death. Additionally, ischemia led to an increased number of PSA-NCAM-positive NPCs close to the lateral ventricular walls, compared with brains of comparable age without obvious neuropathologic changes. These results suggest that the adult human brain retains a capacity to respond to ischemic injuries and that this capacity is maintained even in old age. ER -