PT  - JOURNAL ARTICLE
AU  - Naoya Yamashita
AU  - Yutaka Uchida
AU  - Toshio Ohshima
AU  - Syu-ichi Hirai
AU  - Fumio Nakamura
AU  - Masahiko Taniguchi
AU  - Katsuhiko Mikoshiba
AU  - Jérôme Honnorat
AU  - Pappachan Kolattukudy
AU  - Nicole Thomasset
AU  - Kohtaro Takei
AU  - Takuya Takahashi
AU  - Yoshio Goshima
TI  - Collapsin Response Mediator Protein 1 Mediates Reelin Signaling in Cortical Neuronal Migration
AID  - 10.1523/JNEUROSCI.4276-06.2006
DP  - 2006 Dec 20
TA  - The Journal of Neuroscience
PG  - 13357--13362
VI  - 26
IP  - 51
4099  - http://www.jneurosci.org/content/26/51/13357.short
4100  - http://www.jneurosci.org/content/26/51/13357.full
SO  - J. Neurosci.2006 Dec 20; 26
AB  - Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that mediates signal transduction of axon guidance molecules. Here, we show evidence that CRMP1 is involved in Reelin (Reln) signaling to regulate neuronal migration in the cerebral cortex. In crmp1−/− mice, radial migration of cortical neurons was retarded. This phenotype was not observed in the sema3A−/− and crmp1+/−;sema3A+/− cortices. However, CRMP1 was colocalized with disabled-1 (Dab1), an adaptor protein in Reln signaling. In the Relnrl/rl cortex, CRMP1 and Dab1 were expressed at a higher level, yet tyrosine phosphorylated at a lower level. Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling.