RT Journal Article
SR Electronic
T1 Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 304
OP 307
DO 10.1523/JNEUROSCI.4433-06.2007
VO 27
IS 2
A1 Yaoming Wang
A1 Xiao Ou Mao
A1 Lin Xie
A1 Surita Banwait
A1 Hugo H. Marti
A1 David A. Greenberg
A1 Kunlin Jin
YR 2007
UL http://www.jneurosci.org/content/27/2/304.abstract
AB We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF+/+). We report that SOD1G93A/VEGF+/+ double-transgenic mice show delayed motor neuron loss, delayed motor impairment, and prolonged survival compared with SOD1G93A single transgenics. These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS.