RT Journal Article
SR Electronic
T1 Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6029
OP 6036
DO 10.1523/JNEUROSCI.5441-06.2007
VO 27
IS 22
A1 Jamie Purzner
A1 Guillermo O. Paradiso
A1 Danny Cunic
A1 Jean A. Saint-Cyr
A1 Tasnuva Hoque
A1 Andres M. Lozano
A1 Anthony E. Lang
A1 Elena Moro
A1 Mojgan Hodaie
A1 Filomena Mazzella
A1 Robert Chen
YR 2007
UL http://www.jneurosci.org/content/27/22/6029.abstract
AB The subthalamic nucleus (STN) is part of the cortico-basal ganglia (BG)–thalamocortical circuit, whereas the ventral lateral nucleus of the thalamus (VL) is a relay nucleus in the cerebello-dentato-thalamocortical (CTC) pathway. Both pathways have been implicated in movement preparation. We compared the involvement of the STN and VL in movement preparation in humans by recording local field potentials (LFPs) from seven patients with Parkinson's disease with deep-brain stimulation (DBS) electrodes in the STN and five patients with tremor and electrodes in VL. LFPs were recorded from DBS electrodes and scalp electrodes simultaneously while the patients performed self-paced and externally cued (ready, go/no-go) movements. For the self-paced movement, a premovement-related potential was observed in all patients from scalp, STN (phase reversal, five of six patients), and VL (phase reversal, five of five patients) electrodes. The onset times of the potentials were similar in the cortex, STN, and VL, ranging from 1.5 to 2 s before electromyogram onset. For the externally cued movement, an expectancy potential was observed in all patients in cortical and STN electrodes (phase reversal, six of six patients). The expectancy potential was recorded from the thalamic electrodes in four of five patients. However, phase reversal occurred only in one case, and magnetic resonance imaging showed that this contact was outside the VL. The cortico-BG–thalamocortical circuit is involved in the preparation of both self-paced and externally cued movements. The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements.