TY - JOUR T1 - The Role of <em>Foxg1</em> and Dorsal Midline Signaling in the Generation of Cajal-Retzius Subtypes JF - The Journal of Neuroscience JO - J. Neurosci. SP - 11103 LP - 11111 DO - 10.1523/JNEUROSCI.1066-07.2007 VL - 27 IS - 41 AU - Carina Hanashima AU - Marie Fernandes AU - Jean M. Hebert AU - Gord Fishell Y1 - 2007/10/10 UR - http://www.jneurosci.org/content/27/41/11103.abstract N2 - Cajal-Retzius (CR) cells, the earliest-born neurons in the neocortex, arise from discrete sources within the telencephalon, including the dorsal midline and the pallial–subpallial boundary (PSB). In particular, the cortical hem, a region of high bone morphogenetic proteins (BMPs) and Wnt (wingless-type MMTV integration site family) expression but lacking in Foxg1 (forkhead box G1) is a major source of CR neurons. Whether CR cells from distinct origins arise from disparate developmental processes or share a common mechanism is unclear. To elucidate the molecular basis of CR cell development, we assessed the role of both Foxg1 and dorsal midline signaling in the production of cortical hem- and PSB-derived CR cells. We demonstrate that the loss of Foxg1 results in the overproduction of both of these CR populations. However, removal of Foxg1 at embryonic day 13, although expanding the number of CR cells with a PSB phenotype, does not result in an expansion of BMPs or Wnts in the dorsomedial signaling center. Conversely, loss of the dorsal midline ligands as observed in Gli3 (glioma-associated oncogene homolog 3) mutants results in the loss of the cortical hem-derived CR character but does not affect the specification of PSB-derived CR cells. Hence, our findings demonstrate that, although the specification of cortical hem-derived CR cells is dependent on signaling from the dorsal midline, Foxg1 functions to repress the generation of both cortical hem- and PSB-derived CR cells. ER -