@article {Jiang9648, author = {Bin Jiang and Mario Trevi{\~n}o and Alfredo Kirkwood}, title = {Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex}, volume = {27}, number = {36}, pages = {9648--9652}, year = {2007}, doi = {10.1523/JNEUROSCI.2655-07.2007}, publisher = {Society for Neuroscience}, abstract = {Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.}, issn = {0270-6474}, URL = {https://www.jneurosci.org/content/27/36/9648}, eprint = {https://www.jneurosci.org/content/27/36/9648.full.pdf}, journal = {Journal of Neuroscience} }