PT - JOURNAL ARTICLE AU - Bin Jiang AU - Mario TreviƱo AU - Alfredo Kirkwood TI - Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex AID - 10.1523/JNEUROSCI.2655-07.2007 DP - 2007 Sep 05 TA - The Journal of Neuroscience PG - 9648--9652 VI - 27 IP - 36 4099 - http://www.jneurosci.org/content/27/36/9648.short 4100 - http://www.jneurosci.org/content/27/36/9648.full SO - J. Neurosci.2007 Sep 05; 27 AB - Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.