RT Journal Article SR Electronic T1 Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 9648 OP 9652 DO 10.1523/JNEUROSCI.2655-07.2007 VO 27 IS 36 A1 Bin Jiang A1 Mario TreviƱo A1 Alfredo Kirkwood YR 2007 UL http://www.jneurosci.org/content/27/36/9648.abstract AB Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain modifiable until later ages. We examined whether these laminar differences correlate with changes in long-term potentiation (LTP) and long-term depression (LTD) of the ascending pathways to layers IV and II/III in the mouse visual cortex. Our analysis revealed that LTP and LTD in layer IV principal cells is lost shortly after the eyes open, but persists in layers II/III beyond puberty. These results suggest that plasticity proceeds sequentially through cortical layers in a manner that parallels the flow of information during sensory processing.