RT Journal Article SR Electronic T1 Interferon-γ-Oligodendrocyte Interactions in the Regulation of Experimental Autoimmune Encephalomyelitis JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 2013 OP 2024 DO 10.1523/JNEUROSCI.4689-06.2007 VO 27 IS 8 A1 Roumen Balabanov A1 Krystle Strand A1 Rajendra Goswami A1 Eileen McMahon A1 Wendy Begolka A1 Stephen D. Miller A1 Brian Popko YR 2007 UL http://www.jneurosci.org/content/27/8/2013.abstract AB Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human demyelinating disorder multiple sclerosis (MS). The immune cytokine interferon-gamma (IFN-γ) is believed to participate in disease pathogenesis in both EAE and MS. In the present study, we examined the significance of IFN-γ-oligodendrocyte interactions in the course of EAE. For the purpose of our study, we used the previously described [proteolipid protein/suppressor of cytokine signaling 1 (PLP/SOCS1)] transgenic mouse line that displays suppressed oligodendrocyte responsiveness to IFN-γ. PLP/SOCS1 mice developed EAE with an accelerated onset associated with enhanced early inflammation and markedly increased oligodendrocyte apoptosis. Moreover, we found that IFN-γ pretreatment of mature oligodendrocytes in vitro had a protective effect against oxidative stress and the inhibition of proteasome activity and resulted in upregulation in expression of a number of chemokines, including CXCL10 (IP10), CCL2 (MCP-1), CCL3 (MCP-1α), and CCL5 (RANTES). These results suggest that IFN-γ-oligodendrocyte interactions are of significance to the clinical and pathological aspects of EAE. In addition, the present study suggests that oligodendrocytes are not simply targets of inflammatory injury but active participants of the neuroimmune network operating during the course of EAE.