RT Journal Article
SR Electronic
T1 Long-Range Axonal Calcium Sweep Induces Axon Retraction
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4613
OP 4618
DO 10.1523/JNEUROSCI.0019-08.2008
VO 28
IS 18
A1 Ryuji X. Yamada
A1 Takuya Sasaki
A1 Junya Ichikawa
A1 Ryuta Koyama
A1 Norio Matsuki
A1 Yuji Ikegaya
YR 2008
UL http://www.jneurosci.org/content/28/18/4613.abstract
AB Axon guidance molecules trigger a cascade of local signal in growth cones and evoke various morphologic responses, including axon attraction, repulsion, elongation, and retraction. However, little is known about whether subcellular compartments, other than axonal growth cones, control axon outgrowth. We found that in isolated dentate granule cells, local application of glutamate to the somatodendritic areas, but not the axon itself, induced rapid axon retraction, during which a calcium wave propagated from the somata to the axon terminals. The calcium wave and axon retraction were both inhibited by blockade of voltage-sensitive calcium channels and intracellular calcium dynamics. A combination of perisomatic application of calcium ionophore and depolarizing current injection induced axonal calcium sweep and axon retraction. Thus, perisomatic environments can modulate axon behavior through long-range intracellular communication.