PT  - JOURNAL ARTICLE
AU  - Kathryn Hefner
AU  - Nigel Whittle
AU  - Jaynann Juhasz
AU  - Maxine Norcross
AU  - Rose-Marie Karlsson
AU  - Lisa M. Saksida
AU  - Timothy J. Bussey
AU  - Nicolas Singewald
AU  - Andrew Holmes
TI  - Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain
AID  - 10.1523/JNEUROSCI.4904-07.2008
DP  - 2008 Aug 06
TA  - The Journal of Neuroscience
PG  - 8074--8085
VI  - 28
IP  - 32
4099  - http://www.jneurosci.org/content/28/32/8074.short
4100  - http://www.jneurosci.org/content/28/32/8074.full
SO  - J. Neurosci.2008 Aug 06; 28
AB  - Fear extinction is a form of new learning that results in the inhibition of conditioned fear. Trait deficits in fear extinction are a risk factor for anxiety disorders. There are few examples of naturally occurring animal models of impaired extinction. The present study compared fear extinction in a panel of inbred mouse strains. This strain survey revealed an impairment in fear extinction in 129/SvImJ (129S1). The phenotypic specificity of this deficit was evaluated by comparing 129S1 and C57BL/6J for one-trial and multitrial fear conditioning, nociception, and extinction of conditioned taste aversion and an appetitive instrumental response. 129S1 were tested for sensitivity to the extinction-facilitating effects of extended training, as well as d-cycloserine and yohimbine treatment. To elucidate the neural basis of impaired 129S1 fear extinction, c-Fos and Zif268 expression was mapped after extinction recall. Results showed that impaired fear extinction in 129S1 was unrelated to altered fear conditioning or nociception, and was dissociable from intact appetitive extinction. Yohimbine treatment facilitated extinction in 129S1, but neither extended extinction training nor d-cycloserine treatment improved 129S1 extinction. After extinction recall, 129S1 showed reduced c-Fos and Zif268 expression in the infralimbic cortex and basolateral amygdala, and elevated c-Fos or Zif268 expression in central nucleus of the amygdala and medial paracapsular intercalated cell mass, relative to C57BL/6J. Collectively, these data demonstrate a deficit in fear extinction in 129S1 associated with a failure to properly engage corticolimbic extinction circuitry. This common inbred strain provides a novel model for studying impaired fear extinction in anxiety disorders.