@article {Giocomo9414, author = {Lisa M. Giocomo and Michael E. Hasselmo}, title = {Time Constants of h Current in Layer II Stellate Cells Differ along the Dorsal to Ventral Axis of Medial Entorhinal Cortex}, volume = {28}, number = {38}, pages = {9414--9425}, year = {2008}, doi = {10.1523/JNEUROSCI.3196-08.2008}, publisher = {Society for Neuroscience}, abstract = {Chronic recordings in the medial entorhinal cortex of behaving rats have found grid cells, neurons that fire when the rat is in a hexagonal array of locations. Grid cells recorded at different dorsal{\textendash}ventral anatomical positions show systematic changes in size and spacing of firing fields. To test possible mechanisms underlying these differences, we analyzed properties of the hyperpolarization-activated cation current Ih in voltage-clamp recordings from stellate cells in entorhinal slices from different dorsal{\textendash}ventral locations. The time constant of h current was significantly different between dorsal and ventral neurons. The time constant of h current correlated with membrane potential oscillation frequency and the time constant of the sag potential in the same neurons. Differences in h current could underlie differences in membrane potential oscillation properties and contribute to grid cell periodicity along the dorsal{\textendash}ventral axis of medial entorhinal cortex.}, issn = {0270-6474}, URL = {https://www.jneurosci.org/content/28/38/9414}, eprint = {https://www.jneurosci.org/content/28/38/9414.full.pdf}, journal = {Journal of Neuroscience} }