RT Journal Article SR Electronic T1 Quantitative Cortical Mapping of Fractional Anisotropy in Developing Rat Brains JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 1427 OP 1433 DO 10.1523/JNEUROSCI.3194-07.2008 VO 28 IS 6 A1 Hao Huang A1 Akria Yamamoto A1 Mir Ahamed Hossain A1 Laurent Younes A1 Susumu Mori YR 2008 UL http://www.jneurosci.org/content/28/6/1427.abstract AB Cortical development is associated with a series of events that involve axon and dendrite growth and synaptic formation. Although these developmental processes have been investigated in detail with histology, three-dimensional and quantitative imaging methods for rodent brains may be useful for genetic and pharmacological studies in which cortical developmental abnormalities are suspected. It has been shown that diffusion tensor imaging (DTI) can delineate the columnar organization of the fetal and early neonatal cortex based on a high degree of diffusion anisotropy along the columnar structures. This anisotropy is known to decrease during brain development. In this study, we applied DTI to developing rat brains at five developmental stages, postnatal days 0, 3, 7, 11 and 19, and used diffusion anisotropy as an index to characterize the structural change. Statistical analysis reveals four distinctive cortical areas that demonstrate a characteristic time course of anisotropy loss. This method may provide a means to delineate specific cortical areas and a quantitative method to detect abnormalities in cortical development in rodent pathological models.