RT Journal Article
SR Electronic
T1 Dynamic Changes in Brain Activity during Prism Adaptation
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 169
OP 178
DO 10.1523/JNEUROSCI.3054-08.2009
VO 29
IS 1
A1 Jacques Luauté
A1 Sophie Schwartz
A1 Yves Rossetti
A1 Mona Spiridon
A1 Gilles Rode
A1 Dominique Boisson
A1 Patrik Vuilleumier
YR 2009
UL http://www.jneurosci.org/content/29/1/169.abstract
AB Prism adaptation does not only induce short-term sensorimotor plasticity, but also longer-term reorganization in the neural representation of space. We used event-related fMRI to study dynamic changes in brain activity during both early and prolonged exposure to visual prisms. Participants performed a pointing task before, during, and after prism exposure. Measures of trial-by-trial pointing errors and corrections allowed parametric analyses of brain activity as a function of performance. We show that during the earliest phase of prism exposure, anterior intraparietal sulcus was primarily implicated in error detection, whereas parieto-occipital sulcus was implicated in error correction. Cerebellum activity showed progressive increases during prism exposure, in accordance with a key role for spatial realignment. This time course further suggests that the cerebellum might promote neural changes in superior temporal cortex, which was selectively activated during the later phase of prism exposure and could mediate the effects of prism adaptation on cognitive spatial representations.