PT  - JOURNAL ARTICLE
AU  - William J. Berglind
AU  - Timothy W. Whitfield, Jr
AU  - Ryan T. LaLumiere
AU  - Peter W. Kalivas
AU  - Jacqueline F. McGinty
TI  - A Single Intra-PFC Infusion of BDNF Prevents Cocaine-Induced Alterations in Extracellular Glutamate within the Nucleus Accumbens
AID  - 10.1523/JNEUROSCI.5457-08.2009
DP  - 2009 Mar 25
TA  - The Journal of Neuroscience
PG  - 3715--3719
VI  - 29
IP  - 12
4099  - http://www.jneurosci.org/content/29/12/3715.short
4100  - http://www.jneurosci.org/content/29/12/3715.full
SO  - J. Neurosci.2009 Mar 25; 29
AB  - The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and projecting to the nucleus accumbens (NAc) core is a critical component of the reward circuitry that underlies reinstatement to cocaine-seeking behavior. Brain-derived neurotrophic factor (BDNF) is expressed by and modulates PFC–NAc neurons. BDNF infusion into the dmPFC attenuates reinstatement to cocaine-seeking behavior, as well as some cocaine-induced molecular adaptations within the NAc. In the present study, it is demonstrated that a single intra-dmPFC infusion of BDNF prevents cocaine self-administration-induced reduction in basal extracellular glutamate, as well as cocaine prime-induced increases in extracellular glutamate levels within the NAc. These data suggest that intra-PFC BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing cocaine-induced neuroadaptations that alter glutamate neurotransmission within the NAc.