RT Journal Article SR Electronic T1 Functional Connectivity of the Macaque Brain across Stimulus and Arousal States JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 5897 OP 5909 DO 10.1523/JNEUROSCI.0220-09.2009 VO 29 IS 18 A1 Sebastian Moeller A1 Nambi Nallasamy A1 Doris Y. Tsao A1 Winrich A. Freiwald YR 2009 UL http://www.jneurosci.org/content/29/18/5897.abstract AB Cortical networks generate temporally correlated brain activity. To clarify the functional significance of this correlated activity, we asked whether and how its structure depends on stimulus and arousal state. Using independent components analysis of macaque functional magnetic resonance imaging data, we identified a large number of brain networks that were strikingly reproducible across different visual stimulus contexts. Fewer networks were reproducible across alert and anesthetized brain states. Network complexity ranged from bilateral single-node networks to networks comprising multiple discrete nodes distributed over 3 cm of cortex; one network identified in our survey included parts of the temporal parietal occipital junction, dorsal premotor cortex, insula, and posterior cingulate cortex bilaterally. Our results reveal the wealth of spatially structured correlated networks throughout the brain in both alert and anesthetized monkeys, and show that anesthesia significantly alters the spatial structure of these networks.