RT Journal Article SR Electronic T1 Dopamine D4 Receptors Regulate AMPA Receptor Trafficking and Glutamatergic Transmission in GABAergic Interneurons of Prefrontal Cortex JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 550 OP 562 DO 10.1523/JNEUROSCI.5050-08.2009 VO 29 IS 2 A1 Eunice Y. Yuen A1 Zhen Yan YR 2009 UL http://www.jneurosci.org/content/29/2/550.abstract AB GABAergic interneurons in prefrontal cortex (PFC) play a critical role in cortical circuits by providing feedforward and feedback inhibition and synchronizing neuronal activity. Impairments in GABAergic inhibition to PFC pyramidal neurons have been implicated in the abnormal neural synchrony and working memory disturbances in schizophrenia. The dopamine D4 receptor, which is strongly linked to neuropsychiatric disorders, such as attention deficit–hyperactivity disorder (ADHD) and schizophrenia, is highly expressed in PFC GABAergic interneurons, while the physiological role of D4 in these interneurons is largely unknown. In this study, we found that D4 activation caused a persistent suppression of AMPAR-mediated synaptic transmission in PFC interneurons. This effect of D4 receptors on AMPAR-EPSC was via a mechanism dependent on actin/myosin V motor-based transport of AMPA receptors, which was regulated by cofilin, a major actin depolymerizing factor. Moreover, we demonstrated that the major cofilin-specific phosphatase Slingshot, which was activated by calcineurin downstream of D4 signaling, was required for the D4 regulation of glutamatergic transmission. Thus, D4 receptors, by using the unique calcineurin/Slingshot/cofilin signaling mechanism, regulate actin dynamics and AMPAR trafficking in PFC GABAergic interneurons. It provides a potential mechanism for D4 receptors to control the excitatory synaptic strength in local-circuit neurons and GABAergic inhibition in the PFC network, which may underlie the role of D4 receptors in normal cognitive processes and mental disorders.